Morphine-like analgesic actions of enkephalin-like peptides containing the Tyr-Arg unit

A. Nakamura, Hiroshi Takagi, Haruaki Yajima, Hiro Amano, Osamu Nagase, Minoru Kubota

doi:10.1016/0024-3205(82)90129-1

説明

The analgesic actions of some synthetically prepared peptides having the Tyr-D-Arg unit at the N terminal portion of met- and leu-enkephalin were measured by the intra-cisternal injection method in mice. Among them, Tyr-D-Arg-Gly-Phe (DR-4) induced the most potent naloxone-reversible analgesia and was also effective by s.c. injection. DR-4 showed the good affinity to mu-receptor, and the resistance to the enzymatic degradation.

収録刊行物

Life Sciences

Life Sciences 31 2245-2248, 1982-11-01

Elsevier BV

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詳細情報詳細情報について

CRID: 1873116917805653888

DOI: 10.1016/0024-3205(82)90129-1

ISSN: 00243205

PubMed: 6298521

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