- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model
Description
<jats:p>More than 50% of patients with heart failure present with heart failure with preserved ejection fraction (HFpEF), and 80% of them are overweight or obese. In this study we developed an obesity associated pre-HFpEF mouse model and showed an improvement in both systolic and diastolic early dysfunction following fecal microbiome transplant (FMT). Our study suggests that the gut microbiome-derived short-chain fatty acid butyrate plays a significant role in this improvement. Cardiac RNAseq analysis showed butyrate to significantly upregulate <jats:italic>ppm1k</jats:italic> gene that encodes protein phosphatase 2Cm (PP2Cm) which dephosphorylates and activates branched-chain α-keto acid dehydrogenase (BCKDH) enzyme, and in turn increases the catabolism of branched chain amino acids (BCAAs). Following both FMT and butyrate treatment, the level of inactive p-BCKDH in the heart was reduced. These findings show that gut microbiome modulation can alleviate early cardiac mechanics dysfunction seen in the development of obesity associated HFpEF.</jats:p>
Journal
-
- Frontiers in Cardiovascular Medicine
-
Frontiers in Cardiovascular Medicine 10 2023-02-08
Frontiers Media SA
- Tweet
Keywords
- heart failure with preserved ejection fraction
- obesity
- gut microbiome
- Cardiovascular Medicine
- branched chain amino acids (BCAAs); gut microbiome; heart failure with preserved ejection fraction; obesity; short chain fatty acids
- branched chain amino acids (BCAAs)
- RC666-701
- Diseases of the circulatory (Cardiovascular) system
- short chain fatty acids