Prognostic accuracy of shock index for severe postpartum hemorrhage in high-income country: Protocol for a systematic review and meta-analysis

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>This review aims to conduct a systematic review and meta-analysis to assess the prognostic value of shock index for prediction of severe Postpartum hemorrhage (PPH) in high-income countries.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We will perform a systematic review and meta-analysis for diagnostic test accuracy (DTA). We will search CENTRAL, MEDLINE (Ovid), Web of Science, and other sources and include all relevant reports on the prognostic accuracy of shock index for severe PPH. The target condition is defined as severe PPH required higher-level care. Two review authors will independently screen the study eligibility and extract data from included studies. Two authors will also assess study quality using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool. We will use the hierarchical models comprising both the bivariate model and the hierarchical summary receiver operating characteristic (HSROC) model for data synthesis if appropriate. We presented uncertainty of the accuracy estimates using 95% confidence intervals (CIs).</jats:p></jats:sec><jats:sec><jats:title>Trial registration</jats:title><jats:p>This review is submitted with University hospital medical information network clinical trial registry (UMIN-CTR) [UMIN 000044230].</jats:p></jats:sec><jats:sec><jats:title>Conflicts of interest</jats:title><jats:p>All authors declare to have no conflicts of interest</jats:p></jats:sec><jats:sec><jats:title>Funding</jats:title><jats:p>None</jats:p></jats:sec>