Leukocyte accumulation in sparganosis: further characterization of an eosinophil chemotactic factor of the plerocercoid of<i>Spirometra erinacei</i>
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説明
<jats:title>ABSTRACT</jats:title><jats:p>An eosinophil chemotactic factor (ECF) was partially purified from plerocercoids of<jats:italic>Spirometra erinacei</jats:italic>by a combination of anion-exchange chromatography on DE52 and gel filtration on Sephacryl S–200. The molecular weight of ECF was estimated to be 25 000–45 000 by high-pressure liquid chromatography. The ECF was bound with concanavalin A-Sepharose. The ECF was sensitive to periodate oxidation and to heating (56°C, 30 min). On isoelectric focusing, eosinophil chemotactic activity was clearly revealed at pI 4·1. These results suggest that ECF of<jats:italic>S. erinacei</jats:italic>plerocercoid is an acidic glycoprotein. An intradermal injection of ECF induced eosinophil attractions in the normal guinea pig skin.</jats:p>
収録刊行物
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- Journal of Helminthology
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Journal of Helminthology 63 6-12, 1989-03-01
Cambridge University Press (CUP)