Synthesis of polycyclic nitrogen‐containing heterocyclic: One pot formation of 1,6‐naphthyridine ring system by reaction of amino‐cyano‐methylthio‐heterocycles with dialkyl acetyeledicarboxylates
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説明
<jats:title>Abstract</jats:title><jats:p>Reaction of 3‐amino‐3‐methylthio‐2‐cyanoacrylonitrile (1) with excess dimethyl acetylenedi‐carboxylate(DMAD) in the presence of potassium carbonate in dimethyl sulfoxide gave a novel tricyclic heterocycle, hexamethyl l<jats:italic>H</jats:italic>‐1,4,7‐triazaphenalene‐2,3,5,6,8,9‐hexacarboxylate (<jats:bold>5a</jats:bold>). When one equivalent of DMAD was used in this reaction, dimethyl 4‐amino‐3‐cyano‐2‐methylthiopyridine‐5,6‐dicarboxylate (<jats:bold>3a</jats:bold>), a key intermediate of <jats:bold>5a</jats:bold>, was obtained.</jats:p>
収録刊行物
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- Journal of Heterocyclic Chemistry
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Journal of Heterocyclic Chemistry 38 1135-1141, 2001-09-01
Wiley