Mechanism of desensitization in taste responses: Prolongation of frog taste nerve responses to bitter substances by adapting the tongue to CaCl2 solution

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Abstract 1. 1. The taste nerve responses to bitter substances declined rapidly to the spontaneous level during stimulation, but were remarkably prolonged when the tongue was stimulated after adapting to CaCl 2 solution. 2. 2. The prolongation of the responses (inhibition of desensitization) to bitter substances was not inhibited by the Ca-channel blockers, suggesting that the inhibition of the desensitization occurs not inside taste cells but at membrane level.

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