Differential potential of endothelial progenitor cells to promote arteriogenesis and angiogenesis

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showed olygoclonal distributions (12%) and even absence of TCRBV families (3%). Before treatment, patients showed a higher expression of BV7 andBV23 families compared with healthy individuals. At baseline, healthy donors showed a significantly higher complexity score (170.8±5.6) compared to CAD patients (141.6±15.3) (P=.01). Three months after BMC injection, all patients showed an improvement in the complexity score (152.4±14.3) thus abolishing the difference previously found with healthy donors. Conclusion: Intramyocardial injection of autologous BMC may have a systemic effect on the immune system favoring the recovery of TCR BV repertoire diversity and profile in patients with advanced CAD undergoing TMLR.

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