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Recent trend of androgen deprivation therapy in newly diagnosed prostate cancer patients: Comparing between high‐ and middle‐income Asian countries
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- Jasmine Lim
- Department of Surgery Faculty of Medicine University of Malaya Kuala Lumpur Malaysia
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- Mizuki Onozawa
- Department of Urology School of Medicine International University of Health and Welfare Chiba Japan
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- Marniza Saad
- Department of Clinical Oncology University of Malaya Medical Centre Faculty of Medicine University of Malaya Kuala Lumpur Malaysia
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- Teng Aik Ong
- Department of Surgery Faculty of Medicine University of Malaya Kuala Lumpur Malaysia
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- Rohan Malek
- Department of Urology Selayang Hospital Ministry of Health Malaysia Selangor Malaysia
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- Hideyuki Akaza
- Strategic Investigation on Comprehensive Cancer Network Interfaculty Initiative in Information Studies/Graduate School of Interdisciplinary Information University of Tokyo Tokyo Japan
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Description
<jats:title>Abstract</jats:title><jats:p>The number of newly diagnosed prostate cancer cases varies across Asia, with higher mortality‐to‐incidence ratio reported in developing nations. Androgen deprivation therapy (ADT), alone or in combination, remains the mainstay of first‐line treatment for advanced prostate cancer. Key findings of extensive research and randomized controlled trials have shaped current clinical practice and influenced clinical guideline recommendations. We describe here the recent trend of ADT in newly diagnosed prostate cancer for Asia focusing on Japan (high‐income country) and Malaysia (middle‐income country) based on the Asian Prostate Cancer (A‐CaP) Study. The combination of radiotherapy and ADT or ADT alone was common in patients with intermediate‐to‐high risk localized and locally advanced disease. For metastatic prostate cancer, maximum androgen blockade (gonadotrophin‐releasing hormone [GnRH] agonist/antagonist plus antiandrogen) was prevalent among the Japanese patients while primary ADT alone with GnRH agonist/antagonist was widely practiced in the Malaysian cohort. Upfront combined therapy (ADT plus docetaxel or androgen receptor pathway inhibitor) has significantly improved the outcomes of patients with metastatic castration‐naïve prostate cancer. Its application, however, remains low in our cohorts due to patients’ financial capacity and national health insurance coverage. Early detection remains the cornerstone in prostate cancer control to improve treatment outcome and patient survival.</jats:p>
Journal
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- Cancer Science
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Cancer Science 112 (6), 2071-2080, 2021-05-03
Wiley
