Two distinct conformational isomers of the 16-membered epoxyenone, the key synthetic intermediate of maridonolides. Conformational analysis and completely stereoselective reduction of the C9 carbonyl group1)

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Abstract The key synthetic intermediate of maridonolides ( 2 ) has two easily detectable conformational isomers in solution. The conformational analysis of the 16-membered epoxyenone ring and the effect of conformation on reactivity in the reduction of the C9 carbony group are described.

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