Inhibition of CXCL4-CCL5 Chemokine Interaction Ameliorates the Development of Abdominal Aortic Aneurysm in Mice

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1.05 / 0.11mm and 1.24 / 0.09mm in the 3-minute time group (p NS between groups). Intimal hyperplasia was modest in all rats, with no significant differences in intimal wall areas. The intimal and medial wall area as a percentage of overall vessel area was 35.0 / 5.2% in the 30-second group and 36.8 / 6.6% in the 3-minute group (p NS). Conclusions: Prolonged balloon inflation time failed to produce significant changes in intimal disruption after 24 hours. At 30 days, there was no difference in the amount of intimal hyperplasia, medial wall thickening, or lumen diameter compared to standard inflation times. These results do not support changing current balloon angioplasty practices.

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