Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
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説明
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Coronavirus disease 2019 (COVID-19) can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of the immune system causing an excessive inflammation including the cytokine storm.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this study, we report that severe acutely infected patients have high levels of both type-1 and type-2 cytokines.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Our results show abnormal cytokine levels upon T-cell stimulation, in a nonpolarized profile. Furthermore, our findings indicate that this hyperactive cytokine response is associated with a significantly increased frequency of late-differentiated T cells with particular phenotype of effector exhausted/senescent CD28−CD57+ cells. Of note, we demonstrated for the first time an increased frequency of CD3+CD4+CD28−CD57+ T cells with expression of programmed death 1, one of the hallmarks of T-cell exhaustion.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These findings reveal that COVID-19 is associated with acute immunodeficiency, especially within the CD4+ T-cell compartment, and points to possible mechanisms of loss of clonal repertoire and susceptibility to viral relapse and reinfection events.</jats:p></jats:sec>
収録刊行物
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- The Journal of Infectious Diseases
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The Journal of Infectious Diseases 2021-08-24
Oxford University Press (OUP)