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The metabolism of 1-phenyl-2-(<i>N</i>-methyl-<i>N</i>-benzylamino)propane (benzphetamine)<i>in vivo</i>in the rat
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Description
1. The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (benzphetamine) was studied in vivo in the rat. 2. Nine metabolites were obtained from urine after oral administration of benzphetamine to rats. The major metabolite, identified as 1-(p-hydroxyphenyl)-2-(N-benzylamino)propane, was formed by aromatic hydroxylation and N-demethylation. One of the minor metabolites was methamphetamine, formed by N-debenzylation. 3. Metabolites excreted in three days after administration of the drug amounted to about 40% of the dose.
Journal
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- Xenobiotica
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Xenobiotica 12 617-625, 1982-01-01
Informa UK Limited
