Electrochemical gene detection by using adamanthyl naphthalene diimide coupled with ferrocenyl- -cyclodextrin
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説明
The adamantyl moieties of adamantylnaphthalene diimide (AND) can be incorporated into the cavity of ferrocenyl-beta-cyclodextrin even where they are bound to double stranded DNA by threading intercalation. When this ternary complex is formed on the DNA probe-immobilized electrode, electrochemical DNA detection is feasible: the electrode hybridized with target DNA gave rise to a current peak corresponding to the ferrocene oxidation upon treatment with AND and ferrocenyl-beta-cyclodextrin (Fc-beta-CD).
収録刊行物
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- Nucleic Acids Symposium Series
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Nucleic Acids Symposium Series 48 103-104, 2004-11-01
Oxford University Press (OUP)