Charge heterogeneity of heat-labile enterotoxins from human enterotoxigenic<i>Escherichia coli</i>
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説明
We purified heat-labile enterotoxins (LThs) from YT3, H-10407 and YT240 strains isolated from human diarrheal patients. These LThs were immunologically identical to each other. The molecular weights of their A and B subunits were also the same by means of SDS-polyacrylamide gel electrophoresis. However, the ionic charges of the molecular surfaces of these LThs were different as shown by polyacrylamide gel isoelectric focusing. Though the pI points of B subunits of the LThs were identical to each other, the pI points of A subunits were found to be different. These data suggest that the ionic charge differences among A subunits cause differences in holo LThs in their charge, and that there is heterogeneity among A subunits produced by strains of human enterotoxigenic Escherichia coli.
収録刊行物
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- FEMS Microbiology Letters
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FEMS Microbiology Letters 61 1-6, 1989-10-01
Oxford University Press (OUP)