Local stimulation to single cell on tissue-mimicking microfluidic device

Masao Washizu, Teru Okitsu, Hidetoshi Kotera, Takaaki Suzuki, Atsuhito Okonogi, Kyohei Terao

doi:10.1109/sensor.2009.5285887

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Local stimulation to single cell on tissue-mimicking microfluidic device

DOI

Masao Washizu
Teru Okitsu
Hidetoshi Kotera
Takaaki Suzuki
Atsuhito Okonogi
Kyohei Terao

説明

In this paper, we developed a novel device for the analysis of intracellular response to external stimulus in single-cell level with high-spatial resolution that simulates in vivo tissue micro-environment. We utilized multidirectional UV lithography technique to realize simple 3-dimentional fabrication of the tissue-mimicking device. Microchannel with an aperture at its sidewall was fabricated. Localized delivery of stimuli to single cell was demonstrated here.