Super-Delayed Changes of Muscarinic Acetylcholine Receptor in the Gerbil Hippocampus Following Transient Ischemia
説明
Cases of sequelae of cerebrovascular disease such as vascular dementia due to death of many neurons have been gradually increasing. Such neuronal death following brain ischemia has been considered to be due to energy deficiency resulting from an impaired respiratory chain. However, analysis of the delayed neuronal death showed that neuronal death is not caused by mere energy deficiency. Most studies on delayed neuronal death focused on the morphological changes and energy metabolism in the acute to subacute stage. There are few reports concerning biochemical changes in the chronic stage, especially in neurotransmitter receptors.
