Changes in the amino acid pool in a nickel-resistant strain of<i>Saccharomyces cerevisiae</i>

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In a Ni-resistant strain of S. cerevisiae, the histidine content of the amino acid pool was increased by culture in a Ni-supplemented medium, while the content of other amino acids was decreased. The toxicity of nickel to yeast was reduced by addition of histidine to the medium. It is concluded that histidine content plays an important role in Ni-resistance in yeast.

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