Recent Progress in Palladium-Catalyzed Cascade Cyclizations for Natural Product Synthesis

DOI

Description

<jats:p>Cascade reactions (also represented as domino reactions) realize the step-economical direct construction of natural product core structures. The use of atom-economical elementary reactions in cascade processes can minimize waste production and avoid prefunctionalization of the substrates. Palladium catalysis, which promotes a variety of atom-economical elementary reactions, has long been used as a powerful approach to the direct formation of complex heterocycles. In this short review, palladium-catalyzed cascade reactions for the construction of core structures of natural products reported in the last decade­ are highlighted.</jats:p><jats:p>1 Introduction</jats:p><jats:p>2 Reactions Terminated with Heteronucleophiles</jats:p><jats:p>2.1 Termination with Nitrogen Nucleophiles</jats:p><jats:p>2.2 Termination with Oxygen Nucleophiles</jats:p><jats:p>3 Reactions Terminated with Carbon Functional Groups</jats:p><jats:p>3.1 Termination with Carbon Nucleophiles</jats:p><jats:p>3.2 Termination with Heck-Type Reactions</jats:p><jats:p>4 Conclusion</jats:p>

Journal

  • Synthesis

    Synthesis 50 700-710, 2018-01-22

    Georg Thieme Verlag KG

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