Thyroid hormone, all‐trans retinoic acid, and 9‐cis retinoic acid functioned as negative modulators of the effect of glucocorticoid on induction of α1‐acid glycoprotein mRNA in RLN‐10 cells
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The expression of acute‐phase protein genes is controlled by many factors, such as IL‐1, IL‐6, glucocorticoids, thyroid hormone (T3), and retinoic acids. We studied the interaction of T3, glucocorticoids, all‐trans retinoic acid (RA), and 9‐cis retinoic acid (9cRA) on the expression of the rat α1‐acid glycoprotein (AGP) gene in vitro. Dexamethasonc (Dex) activated AGP gene expression in a rat liver derived cell line, RLN‐10. Although T3, RA, and 9cRA by themselves had no effect on AGP production, they reduced the response to Dex of the AGP gene.</jats:p>
収録刊行物
-
- IUBMB Life
-
IUBMB Life 45 1-10, 1998-06-01
Wiley