A Viral Non‐Coding Region Determining Neuropathogenicity of Murine Leukemia Virus A8 Is Responsible for Envelope Protein Expression in the Rat Brain
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説明
<jats:title>Abstract</jats:title><jats:p>Friend murine leukemia virus clone A8 causes spongiform neurodegeneration in the rat brain. A 0.3‐kb fragment containing the R‐U5–5′ leader sequence of A8 is required in addition to the A8‐<jats:italic>env</jats:italic> gene to induce spongiosis. The A8‐<jats:italic>env</jats:italic> gene is a primary determinant of neuropathogenicity. Comparative studies of the neuropathogenic virus R7f, which carries the 0.3‐kb fragment of A8 and A8‐<jats:italic>env</jats:italic> on the background of the non‐neuropathogenic clone 57, and the non‐neuropathogenic virus Rec5, which carries A8‐<jats:italic>env</jats:italic> on the background of 57, showed that the 0.3‐kb fragment of A8 was responsible for increasing the ratio of Env/Gag expression in the brain, but not in the spleen.</jats:p>
収録刊行物
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- Microbiology and Immunology
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Microbiology and Immunology 50 197-201, 2006-03-01
Wiley