Protease activity of influenza virus RNA polymerase PA subunit
説明
Abstract Influenza virus RNA polymerase is a multifunctional enzyme that catalyzes both transcription and replication of the RNA genome. The function of the influenza virus RNA polymerase PA subunit in viral replication is poorly understood although the enzyme is known to be required for cRNA→vRNA synthesis. Protease related activity of PA has been discussed ever since protease-inducing activity was demonstrated in transfection experiments. PA protein was highly purified from baculovirus-infected insect cells and a novel chymotrypsin-type serine protease activity with serine624 as an active site was identified in the protein. These results constitute the first demonstration of protease activity in RNA polymerase complexes.
収録刊行物
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- International Congress Series
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International Congress Series 1219 479-485, 2001-10-01
Elsevier BV
