説明
<jats:p>Reproductive isolation occurs when the genomes of two populations accumulate genetic incompatibilities that prevent inter-breeding. Cell biological understanding of such hybrid incompatibility is limited, especially for hybrid female sterility. Here we find that species divergence in condensin regulation and centromere organization between two mouse species,<jats:italic>Mus musculus</jats:italic>and<jats:italic>Mus spretus</jats:italic>, drives chromosome de-condensation and mis-segregation in their F1 hybrid oocytes, reducing female fertility. The chromosome condensation defects in hybrid oocytes were especially prominent at<jats:italic>Mus musculus</jats:italic>centromeres due to their highly abundant major satellite DNA, leading to species-specific chromosome mis-segregation. This study provides the first mechanistic insights into hybrid incompatibility in female meiosis and demonstrates that condensin mis-regulation can be a reproductive isolating barrier in mammals.</jats:p>
収録刊行物
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- Nature
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Nature 623 347-355, 2022-10-21
Cold Spring Harbor Laboratory
