Convenient Synthesis of Acyclic Guanidines from Isothiouronium Iodides and Amines without Protection of the Amino Groups
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説明
Acyclic guanidines were obtained in one step by reaction of isothiouronium iodides with an equimolar amount of various amines in tetrahydrofuran. The reactions proceeded under ambient conditions without N-protection/deprotection to afford the corresponding substituted guanidines in quantitative yields.
収録刊行物
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- Synlett
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Synlett 25 983-986, 2014-03-18
Georg Thieme Verlag KG