Changes in cAMP and cGMP levels induced by relaxing drugs in acetylcholine- and potassium-treated molluscan smooth muscle

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Abstract 1. 1. The changes of cAMP and cGMP levels in response to serotonin, dopamine, papaverine and Aspaminol were investigated in acetylcholine- and potassium-treated molluscan smooth muscle in accordance with the time course of contraction-relaxation process in mechanical response to acetylcholine and potassium. 2. 2. Acetylcholine (10−5 M) and potassium (229 mM) had no influences on basal cAMP and cGMP levels. 3. 3. Serotonin (10−6 M and 10−5 M) dose-dependently elevated cAMP level and serotonin (10−5 M) reduced cGMP level in acetylcholine-treated muscle. 4. 4. Serotonin (10−5 M) elevated cAMP level and reduced cGMP level in potassium-treated muscle. 5. 5. Dopamine (10−6M and 10−5M), papaverine (10−4M) and Aspaminol (10−4M) had no effect on cAMP and cGMP level in acetylcholine- and potassium-treated muscle. 6. 6. Relaxing effect of serotonin may be associated with elevated cAMP level and reduced cGMP level at the pharmacological but not physiological level.

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