- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Automatic Translation feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
PC3 Expression In Normal Rat Cochlea
Search this article
Description
Introduction Pheocromocytoma cell-3 (PC3TIS21/BTG2) is a member of the antiproliferative gene family that includes BTG1, PC3B, ANA/BTG3, Tob, and Tob2. Potential roles of PC3 have been suggested: transcriptional coregulator; differentiation factor in neurogenesis; key mediator of the stage-specific expansion of thymocyte; negative regulator of hematopoietic progenitor expansion; and tumor suppressor gene in both mice and humans1. Recent data demonstrated that PC3 induces the differentiation of neurons in vitro and in vivo. In vitro, PC3 potentiates NGF-induced differentiation of PC12 cells and protects neurons from apoptosis2. In vivo, PC3 overexpression in the cerebellum arrests proliferation and increases differentiation of the granule cell progenitors3. PC3 is probably a key gene in the control of the shift from proliferation to differentiation in the central nervous system.
Journal
-
- The Laryngoscope
-
The Laryngoscope 119 2009-01-01
Wiley
- Tweet
Details 詳細情報について
-
- CRID
- 1874242817261418368
-
- ISSN
- 15314995
- 0023852X
-
- Data Source
-
- OpenAIRE
