Loss-of-function mutations in Zn-finger DNA-binding domain of
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説明
Hepatocyte nuclear factors (HNF) are transcription factors that crucially regulate cell-specific gene expression in many tissues, including the liver. Of these factors, HNF4A acts both as a master regulator of liver organogenesis and a tumor suppressor in the liver. In our whole genome sequencing analysis, we found seven somatic mutations (three Zn-finger mutations, three deletion mutants, and one intron mutation) of
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- Oncotarget
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Oncotarget 9 (40), 2017-09-22
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