A facile one-pot preparation of 2-methyl-and 2-phenyl-4- fluoro-5-trifluoromethyl-6-methoxypyrimidine from methyl 2-hydryl-2-(-methyl)--propyl ether

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Abstract The title compounds were readily prepared in one-pot by phase-transfer reaction of a methanol adduct of 2-( F -methyl)- F - propene with acetamidine or benzamidine in the presence of aqueous sodium hydroxide in CH2Cl2. Various 5-trifluoromethyl- pyrimidines were also synthesized via nucleophilic substitution of the 4-fluorine of the title compounds.

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