Synthesis, antithrombogenicity and gas permeability of copolypeptides having silyl groups or dimethylsiloxane oligomers substituted in the side chains

DOI

書誌事項

公開日
1988-06-01
DOI
  • 10.1016/0141-8130(88)90044-x
公開者
Elsevier BV

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Abstract Polypeptides carrying silyl groups or dimethylsiloxane oligomers in the side chains were synthesized. Water contact angles of poly(γ-benzyl l -glutamate)s, which were partly substituted with dimethylsiloxane oligomers in the side chains, were higher than those of poly(γ-benzyl l -glutamate)s, which were partly substituted with silyl groups in the side chains. The latters were higher than those of poly(γ-benzyl l -glutamate). Antithrombogenicity of poly(γ-benzyl l -glutamate) was improved by the substitution of side chains with silyl groups or dimethylsiloxane oligomers. The improvement of antithrombogenicity by the hydrophobic substitution was ascribed to the suppression of platelet adhesion and activation of adhered platelets due to inactivated surfaces. Oxygen permeation coefficients of poly(γ-benzyl l -glutamate) substituted in the side chains with silyl groups or dimethylsiloxane oligomers were 11.5 or 23 times as large respectively as that of poly(γ-benzyl l -glutamate). The increased oxygen permeability by the hydrophobic substitution was ascribed mainly to increased diffusion of oxygen through the film due to decreased packing of molecular chains by the substitution.

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