Response: Meaningless minis?

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hypothesis. We are proposing that the agent that triggers receptor clustering at the postsynaptic membrane is released by the same mechanism as minis [1]. If the agent is contained in the large dense-cored vesicles, it is released with the same mechanism as clear vesicles. By contrast, the non-vesicular hypothesis [2] is proposed to explain different sizes of receptor clusters in various mutants, and postulates that non-vesicular release of glutamate downregulates the cluster size. It should be noted that receptor clusters have to form before this mechanism can work. The major differences between our work and that of Featherstone et al. are that the latter demonstrated receptor clusters by immunofluorescence staining in Drosophila embryos with the null allele syx∆229 in ventral muscle number 6 [2], whereas we did not detect such immunofluorescence in dorsal muscles 1 and 9 of embryos with the Response: Meaningless minis?

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