Studies on chemical modification of monensin VIII. Synthesis of 7-O-substituted-25-carboxymonensins and their Ca2+ ion transport activity

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Abstract Monensin (1), an ionophore antibiotic agent, was converted to 25-carboxymonensin (2) and 7-O-substituted-25-carboxyl derivatives (3a–d), which have two carboxyl groups at both ends of the molecule. Ca2+ ion transport activity of the dicarboxylic monensins was evaluated by the CHCl3 liquid membrane method, and 25-carboxymonensins (2 and 3a–d) were shown to transport the Ca2+ ion through the CHCl3 liquid membrane.

収録刊行物

  • Tetrahedron

    Tetrahedron 57 3005-3012, 2001-04-01

    Elsevier BV

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