Coenzyme models. 15. A polymeric model system for the NADH‐dependent dehydrogenase enzymes

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<jats:title>Abstract</jats:title><jats:p>Copolymers of 4‐vinylpyridine (4‐VP) and <jats:italic>N</jats:italic>‐(<jats:italic>p</jats:italic>‐vinylbenzyl)‐1,4‐dihydronicotinamide (VNicH) were synthesized, and a carbonyl substrate (benzil) was reduced to alcohol in an aqueous ethanol solution in the absence and presence of metal ions (Zn<jats:sup>2+</jats:sup> and Ni<jats:sup>2+</jats:sup>) as part of a model study of NADH‐dependent enzymes. The reduction rates by VNicH in polymers were four to seven times greater than that of the corresponding monomeric analog (<jats:italic>N</jats:italic>‐benzyl‐1,4‐dihydronicotinamide). Added metal ions catalyzed the reduction by VNicH‐29 (VNicH content, 29 mole%) but inhibited the reduction by VNicH‐9 (VNicH content, 9 mole%). It was suggested that metal catalysis occurs only when metal ions are bound closely near the dihydronicotinamide moiety.</jats:p>

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