AB0321 MORTALITY AND COMPLICATION OF PATIENTS WITH RHEUMATOID ARTHRITIS ADMITTED TO INTENSIVE CARE UNIT IN KYUSHU UNIVERSITY HOSPITAL

Background The patients with rheumatoid arthritis (RA) are associated with high mortality caused by comorbidity and complication, and are often required the intensive treatment. Severe infections are among the most common causes of their mortality in intensive care unit (ICU)1)2). Objectives To determine prognostic factors and mortality in patients with RA, including juvenile idiopathic arthritis (JIA), admitted to the ICU in Kyushu University Hospital, we examined the treatments of RA and JIA, comorbidities, complications, the reasons admitted to the ICU, intensive treatments, mortalities within 30 days, 90 days, and a year. Methods Between January 2008 and March 2018, 70 patients (20 males, 50 females) with RA (68) or JIA (2) staying at the ICU of our institution for 48 hours and over were included in this study. The admission to the ICU were performed total 77 of times because 5 patients were readmitted. The average of age and RA duration at the admission was 65.817.7 years (5-96) and 13.514.8 years (0-61), respectively, and the average of follow-up duration was 879.9992.0 days (3-3988). Results The mortality within 30 and 90 days were 21.4% (15/70) and 27.1% (19/70), respectively, and 24 of 65 patients (36.9%), excluded 5 patients due to the change of hospital, were dead within a year. The reasons for ICU admission included cardiovascular complications (22.9%), infection (30.0%), neurological complications (7.1%), respiratory problem (15.7%), gastrointestinal problems (4.3%), endocrinological cause (2.9%), liver problems (7.1%), kidney problems (4.3%), and others (5.7%). The average of ICU length of stay was 7.27.6 days (2-39). The group of 30 days mortality was significantly higher in the amount of prednisone (8.15.8 vs 4.54.9), Charlson Comorbidity Index3) (5.12.5 vs 2.71.4), and APACHEII4) (21.79.2 vs 14.55.5) scores. The fatal outcomes within 30 days was mainly caused by infection (46.7%). In blood data, the low levels of platelet number, total protein, and albumin, and the high levels of creatinine and prothrombin time international normalize ratio at the time of admission of ICU were significantly poorer prognoses. Conclusion Our study has shown the high mortality of RA patients admitted to the ICU, and some blood data could be predicted poor prognosis. References [1] Moreels M, et al.: Intensive Care Med 2005 [2] Brunnler T, et al.: Intern Med 2015 [3] Quan H, et al.: Am J Epidemiol 2011 [4] Knaus WA, et al.: Crit Care Med 1985 Disclosure of Interests