Synthesis of Chiral Prostaglandin (Pge<sub>2</sub>) Via Stork Intermediate By Using Vinylzincates For Conjugate Addition<sup>1</sup>)

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Abstract We report here the synthesis of chiral PGE2 methyl ester as a bissilyl ether via Stork intermediate, which involves the conjugate addition of lithium (E)-vinyldimethylzincate to 4-t-butyldimethylsiloxy-2-cyciopentenone followed by the formaldehyde trapping of the kinetic enolate to give eventually rise to a 2-methylenecyclopentanone derivative, the latter being subjected to the conjugate addition of another (Z)-vinylzincate.

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