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Inhibitory Effect of Oleanene-Type Triterpene Oligoglycosides on Ethanol Absorption : The Structure-Activity Relationships
Description
Alcoholism, which is a major health problem in the world, causes as much trouble physiologically as it dose socially. Excessive consumption of ethanol is known to affect profoundly nearly every organ in the body, particularly the endocrine system, heart, central nervous system, immune system, and liver. In order to relieve ethanol toxicity in acute alcohol ingestion, a couple of methods using an accelerator of ethanol metabolism (e.g. clofibrate, methyl γ-linolenate, ginseng extract)1 and the sequestering of acetaldehyde (e.g. D-penicillamine, L-cysteine)2 have hitherto been reported. In addition, dehydrogenase inhibitors such as cyanamide and disulfiram have been used clinically for chronic alcoholics.3 It is known that dehydrogenase inhibitors force alcoholics to quit drinking based on the fear of unpleasant reaction elicited after ethanol intake, but these drugs are also reported to show many strong side effects.
