α-Adrenolytic activities of apogalanthamine analogs

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Abstract Previously, we reported that an apogalanthamine analog, 6-methyl-5,6,7,8-tetrahydrodibenz[c,e]azocine (DA-VIII-Me) was more potent than phentolamine in α-adrenolytic activity on the rat aorta. In this study, the α1- and α2-adrenolytic activities of azocine derivatives: DA-VIII-Me and its N-allyf analog(DA-VIII-allyl) and azepine derivatives: azapetine and its N-methyl analog(DA-VII-Me) were examined.

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