Stereoselective hydroxylation of N-carbamoyl-L-pyroglutamate. Synthesis of (−)-bulgecinine

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Abstract Regio- and diastereoselective hydroxylation of the monoenolate derived from N- t -butoxycarbonyl-L-pyroglutamate ( 1 ) afforded the optically pure (4 R )-hydroxypyroglutamate ( 2a ) from which (−)-bulgecinine ( 3 ) was synthesized.

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