Neurofilament-light chain quantification by Simoa and Ella in plasma from patients with dementia: a comparative study

Introduction. This database includes the raw data linked with the paper "Neurofilament-light chain quantification by Simoa and Ella in plasma from patients with dementia: a comparative study". Neurofilament light chains (NfL) are neuron-specific cytoskeletal proteins whose plasmatic concentrations have been explored as a clinically useful marker in diagnosing and monitoring several types of dementia. Plasma concentrations of NfL are extremely low, and just two assays are at the moment commercially available for their study: one based on the SiMoA™ technology and a second based on Ella™. We thus studied plasma levels of NfL from patients with Alzheimer’s disease and frontotemporal dementia on both platforms to compare the results obtained. Methods. Plasma NfL levels were measured in parallel using SiMoA™ and Ella™ on 50 subjects: 18 healthy controls, 20 Alzheimer’s disease (AD), and 12 frontotemporal dementia patients (FTD). Results in brief. Plasma NfL levels measured using Ella™ were significantly higher than the one measured by SiMoA™, but the results were strongly correlated (r = 0.94), and a proportional coefficient of 0.58 between the two assays was calculated. Plasma NfL levels were higher in patients with dementia than in the control group on both assays but no difference was found between the two types of dementia.

Funding: Ricerca Corrente 2022-2024" Ministry of Health (Italy) and EuroNanoMed III JTC 2018 project "ABISENS"