Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); University of Rennes; INSERM/Japan Society for the Promotion of Science cooperation programme; Seventh Framework Programme (FP7) LIV-ES [223317]; Contrat Plan Etat Region; Conseil Regional de Bretagne; EU [FP7 267038]; German Federal Ministry of Education and Research (BMBF) [01EK1604A-D]