The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats

The involvement of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids into active glucocorticoids intracellularly, in metabolic diseases and chronic inflammatory diseases has been elucidated. To clarify the role of 11β-HSD1 in chronic periodontitis, the expression of 11β-HSD1 was investigated in an experimental periodontitis model in rats. Experimental periodontitis was induced by silk ligature. The expression of 11β-HSD1 was examined using real time PCR. The expression of 11β-HSD1 mRNA was significantly increased in experimental periodontitis compared with the control. This result suggests that the increased expression of 11β-HSD1, which results in increased levels of intracellular glucocorticoids, may play a role in the pathophysiology of experimental periodontitis.

2016年度

収集根拠 : 博士論文（自動収集）
資料形態 : テキストデータ
コレクション : 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
The involvement of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids into active glucocorticoids intracellularly, in metabolic diseases and chronic inflammatory diseases has been elucidated. To clarify the role of 11β-HSD1 in chronic periodontitis, the expression of 11β-HSD1 was investigated in an experimental periodontitis model in rats. Experimental periodontitis was induced by silk ligature. The expression of 11β-HSD1 was examined using real time PCR. The expression of 11β-HSD1 mRNA was significantly increased in experimental periodontitis compared with the control. This result suggests that the increased expression of 11β-HSD1, which results in increased levels of intracellular glucocorticoids, may play a role in the pathophysiology of experimental periodontitis.
2016年度