Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus

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Bibliographic Information

Title
Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus
Other Title
  • 尿中アディポネクチン排泄は糖尿病患者における腎機能低下の早期予測指標である。
  • Urinary adiponectin in DKD
Author
Ishizu, Masashi
Alias Name
  • 石津, 将
  • イシヅ, マサシ
Author
Mori, Hiroyasu
Alias Name
  • 森, 博康
  • モリ, ヒロヤス
Author
Ohishi, Mami
Alias Name
  • オオイシ, マミ
  • オオイシ, マミ
Author
Kuroda, Akio
Alias Name
  • 黒田, 暁生
  • クロダ, アキオ
Author
Akehi, Yuko
Alias Name
  • アケヒ, ユウコ
  • アケヒ, ユウコ
Author
Yoshida, Sumiko
Alias Name
  • 吉田, 守美子
  • ヨシダ, スミコ
Author
Aihara, Ken-ichi
Alias Name
  • 粟飯原, 賢一
  • アイハラ, ケンイチ
Author
Aiba, Motohiro
Alias Name
  • アイバ, モトヒロ
  • アイバ, モトヒロ
Author
Kawano, Tomoharu
Alias Name
  • カワノ, トモハル
  • カワノ, トモハル
Author
Hashida, Seiichi
Alias Name
  • 橋田, 誠一
  • ハシダ, セイイチ
Author
Matsuhisa, Munehide
Alias Name
  • 松久, 宗英
  • マツヒサ, ムネヒデ
University
徳島大学
Types of degree
博士（医学）
Grant ID
甲医第1489号
Degree year
2021-03-23

Description

Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease. Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR). Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR. Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes.

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