Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis

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Bibliographic Information

Title
Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis
Other Title
  • 子宮内膜症モデルマウスにおいてLPSは腹膜子宮内膜症初期病巣形成を促進する
  • LPS proliferate the endometriosis
Author
Keyama, Kaoru
Alias Name
  • 毛山, 薫
  • ケヤマ, カオル
Author
Kato, Takeshi
Alias Name
  • 加藤, 剛志
  • カトウ, タケシ
Author
Kadota, Yuri
Alias Name
  • 門田, 友里
  • カドタ, ユリ
Author
Erdenebayar, Otgontsetseg
Author
Kasai, Kana
Alias Name
  • カサイ, カナ
  • カサイ, カナ
Author
Kawakita, Takako
Alias Name
  • 河北, 貴子
  • カワキタ, タカコ
Author
Tani, Anna
Alias Name
  • 谷, 杏奈
  • タニ, アンナ
Author
Matsui, Sumika
Alias Name
  • 松井, 寿美佳
  • マツイ, スミカ
Author
Iwasa, Takeshi
Alias Name
  • 岩佐, 武
  • イワサ, タケシ
Author
Yoshida, Kanako
Alias Name
  • 吉田, 加奈子
  • ヨシダ, カナコ
Author
Maegawa, Masahiko
Alias Name
  • マエガワ, マサヒコ
  • マエガワ, マサヒコ
Author
Kuwahara, Akira
Alias Name
  • 桑原, 章
  • クワハラ, アキラ
Author
Matsuzaki, Toshiya
Alias Name
  • 松崎, 利也
  • マツザキ, トシヤ
Author
Irahara, Minoru
Alias Name
  • 苛原, 稔
  • イラハラ, ミノル
University
徳島大学
Types of degree
博士（医学）
Grant ID
甲医第1397号
Degree year
2018-12-27

Description

Purpose : The aims of this study were to clarify the effects of lipopolysaccharide (LPS) on the early development of endometriosis and on the production of cytokines and chemokines in the murine peritoneal cavity. Methods : Endometriotic lesions were induced in C57BL/6J adult female mice by intraperitoneal injection of endometrial fragments plus blood or endometrial fragments plus blood with LPS. On day 7, endometriotic lesions were assessed by gross and microscopic evaluations. Time-dependent changes in the secretion of TNF-α, IL-6, and CXCL2/MIP-2 in peritoneal lavage fluid after the intraperitoneal injection of LPS (50 µg/body) were measured by their respective enzyme-linked immunosorbent assays. Results : The areas of endometriotic lesions in the LPS group (10.8±8.6 mm2) were significantly larger than those in the control group (3.1±3.7 mm2). The levels of TNF-α and IL-6 peaked within 2 hours and the level of MIP-2 reached a maximum on day 1 after the injection of LPS. Conclusions : LPS promotes development of the early stages of murine endometriotic lesions.

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