Genipin inhibits MMP-1 and MMP-3 release from TNF-α-stimulated human periodontal ligament cells

DOI 機関リポジトリ NDLデジタルコレクション

書誌事項

タイトル
Genipin inhibits MMP-1 and MMP-3 release from TNF-α-stimulated human periodontal ligament cells
タイトル別名
  • genipinはTNF-αが誘導するヒト歯根膜細胞のMMP-1およびMMP-3産生を抑制する
著者
進藤, 智
著者別名
  • シンドウ, サトル
  • Shindo, Satoru
著者
細川, 義隆
著者別名
  • ホソカワ, ヨシタカ
  • Hosokawa, Yoshitaka
著者
細川, 育子
著者別名
  • ホソカワ, イクコ
  • Hosokawa, Ikuko
著者
尾崎, 和美
著者別名
  • オザキ, カズミ
  • Ozaki, Kazumi
著者
松尾, 敬志
著者別名
  • マツオ, タカシ
  • Matsuo, Takashi
学位授与大学
徳島大学
取得学位
博士（歯学）
学位授与番号
甲口第425号
学位授与年月日
2017-03-23

説明

Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of inflammatory diseases in traditional oriental medicine. Genipin has recently been reported to have some pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The aim of this study was to examine whether genipin could modify matrix metalloproteinase (MMP)-1 and MMP-3, which are related to the destruction of periodontal tissues in periodontal lesion, expression in tumor necrosis factor (TNF)-a-stimulated human periodontal ligament cells (HPDLCs). Genipin prevented TNF-a- mediated MMP-1 and MMP-3 productions in HPDLCs. Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-a-stimulated HPDLCs. Inhibitors of ERK and AMPK could inhibit both MMP-1 and MMP-3 productions. Moreover, we revealed the ERK inhibitor suppressed AMPK phosphorylation in TNF-a-stimulated HPDLCs. These data provide a new mechanism through which genipin could be used for the treatment of periodontal disease to prevent MMPs expression in periodontal lesion.

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