Clinical significance of altering epithelial-mesenchymal transition (EMT) in metastatic lymph nodes of gastric cancer

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Bibliographic Information

Title
Clinical significance of altering epithelial-mesenchymal transition (EMT) in metastatic lymph nodes of gastric cancer
Other Title
  • 胃癌の転移リンパ節における、EMT変化が与える臨床的意義
Author
Okubo, Keishi
Alias Name
  • 大久保, 啓史
  • オオクボ, ケイシ
University
鹿児島大学
Types of degree
博士(医学)
Grant ID
甲総研第517号
Degree year
2019-08-28

Description

Background: E-cadherin, N-cadherin, and Snail are epithelial-mesenchymal transition (EMT)-inducible genes. Previous studies demonstrated that the expression of EMT markers in the primary tumor sites of gastric cancer correlates with tumor progression and prognosis. However, the clinical significance of the expression of these EMT markers in metastatic lymph nodes remains unclear. In the present study, we investigated the expression of these EMT markers in the primary tumor sites and metastatic lymph nodes. Methods: Immunohistochemistry was used to investigate the expression of E-cadherin, N-cadherin, and Snail in 89 primary tumors and 511 metastatic lymph nodes obtained from patients with gastric cancer. Results: The weak expression of E-cadherin in tumors and lymph nodes increased with more lymph node metastasis and in more undifferentiated tumors. The strong expression of N-cadherin in lymph nodes correlated with more lymph nodes metastasis, an advanced stage and poor prognosis. The weak expression of Snail in tumors correlated with lymphatic invasion. The strong expression of Snail in lymph nodes correlated with more lymph node metastasis and an advanced stage. The strong expression of Snail in tumors and its weak expression in lymph nodes correlated with more lymph node metastasis, an advanced stage, and poor prognosis. Conclusions: The expression of N-cadherin in metastatic lymph nodes is useful for predicting the prognosis of patients with gastric cancer. The Snail switch, namely, the positive-to-negative conversion of the Snail status, between primary tumors and lymph node metastasis may be important for confirming EMT and mesenchymal-to-epithelial transition (MET).

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2023-08-05 再収集

2024-01-19 再収集

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