Bone response around titanium alloy implants in osteoporosis

Few studies have investigated bone healing properties of the extracted tooth socket in osteoporosis. We evaluated the bone's response to mandibular incisor extraction and titanium alloy screw placement in a rat model of osteoporosis both in vitro and in vivo. Ovariectomy (OVX) or a sham operation (control group) was performed at 9 weeks of age. For the in vitro study, alkaline phosphate activity at 7 and 14 days, osteocalcin production at 21 and 28 days, and calcium deposition at 21 and 28 days were measured on titanium alloy disks. For the in vivo study, animal body weights were measured every 3 weeks to observe changes. Titanium alloy screws were placed into the the mandibular incisor extraction sockets. At 3, 6 and 9 weeks post-insertion, histological analyses were performed. At all measured time points, cells of the control group showed significantly more alkaline phosphate activity, osteocalcin production, and calcium deposition than cells of the OVX group. Healing processes of the extraction socket after insertion of a titanium screw differed between the control and OVX groups. Histopathologically, ovariectomized rats showed a marked inhibition of the formation of new bone in the extraction socket.

2014年度

収集根拠 : 博士論文（自動収集）
資料形態 : テキストデータ
コレクション : 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Few studies have investigated bone healing properties of the extracted tooth socket in osteoporosis. We evaluated the bone's response to mandibular incisor extraction and titanium alloy screw placement in a rat model of osteoporosis both in vitro and in vivo. Ovariectomy (OVX) or a sham operation (control group) was performed at 9 weeks of age. For the in vitro study, alkaline phosphate activity at 7 and 14 days, osteocalcin production at 21 and 28 days, and calcium deposition at 21 and 28 days were measured on titanium alloy disks. For the in vivo study, animal body weights were measured every 3 weeks to observe changes. Titanium alloy screws were placed into the the mandibular incisor extraction sockets. At 3, 6 and 9 weeks post-insertion, histological analyses were performed. At all measured time points, cells of the control group showed significantly more alkaline phosphate activity, osteocalcin production, and calcium deposition than cells of the OVX group. Healing processes of the extraction socket after insertion of a titanium screw differed between the control and OVX groups. Histopathologically, ovariectomized rats showed a marked inhibition of the formation of new bone in the extraction socket.
2014年度

収集根拠 : 博士論文（送信）
資料形態 : テキストデータ
コレクション : 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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