Non-invasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using small-animal FDG-PET/CT
書誌事項
- タイトル
- Non-invasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using small-animal FDG-PET/CT
- タイトル別名
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- 甲状腺未分化癌同所移植SCIDマウスモデルへのパクリタキセルとレンバチニブの有効性に対する小動物用FDG-PET/CTを用いた非侵襲的モニタリング
- MONITORING ANAPLASTIC THYROID CANCER MODELS BY PET/CT
- 著者
- (青山)三崎, 万理子
- 著者別名
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- (アオヤマ)ミサキ, マリコ
- Aoyama-Misaki, Mariko
- 著者
- 滝沢, 宏光
- 著者別名
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- タキザワ, ヒロミツ
- Takizawa, Hiromitsu
- 著者
- 大谷, 環樹
- 著者別名
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- オオタニ, タマキ
- Otani, Tamaki
- 著者
- 井上, 聖也
- 著者別名
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- イノウエ, セイヤ
- Inoue, Seiya
- 著者
- 河北, 直也
- 著者別名
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- カワキタ, ナオヤ
- Kawakita, Naoya
- 著者
- 坪井, 光弘
- 著者別名
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- ツボイ, ミツヒロ
- Tsuboi, Mitsuhiro
- 著者
- 坂東, 良美
- 著者別名
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- バンドウ, ヨシミ
- Bando, Yoshimi
- 著者
- 上原, 久典
- 著者別名
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- ウエハラ, ヒサノリ
- Uehara, Hisanori
- 著者
- 近藤, 和也
- 著者別名
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- コンドウ, カズヤ
- Kondo, Kazuya
- 著者
- 丹黒, 章
- 著者別名
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- タンゴク, アキラ
- Tangoku, Akira
- 学位授与大学
- 徳島大学
- 取得学位
- 博士（医学）
- 学位授与番号
- 甲医第1468号
- 学位授与年月日
- 2020-09-24
説明
Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion and the effects of anticancer drugs were evaluated using positron emission tomography/computed tomography (PET/CT) to repeatedly and non-invasively monitor these models. Three ATC cell lines (8305c, 8505c, and ACT-1) were used. Their sensitivities to two anticancer drugs (paclitaxel and lenvatinib) were investigated. The 8505c cell line was orthotopically implanted into SCID mice, which were then divided into three groups: no chemotherapy, paclitaxel (5 mg/kg, administered intraperitoneally, every week), and lenvatinib (5 mg/kg, oral route, every day) groups. PET/CT was performed and tumor growth and the effects of anticancer drugs based on tumor volume and fludeoxyglucose (FDG) uptake were evaluated. 8505c cells exhibited the highest sensitivity to the anticancer drugs. In mice implanted with 8505c cells, continuous increases in FDG uptake associated with tumor growth were detected on PET/CT in the group that received no chemotherapy. The tumor volume and FDG uptake increased by 91.5- and 2.4-fold, respectively, within 2 weeks. The increase observed in tumor volume was 26.9- and 12.2-fold in the paclitaxel and lenvatinib groups, respectively, within 2 weeks. Furthermore, the increase in FDG uptake was 1.8-fold and 1.6-fold in the paclitaxel and lenvatinib groups, respectively, within 2 weeks. In our orthotopic SCID mouse model, tumor growth and the effects of anticancer drugs were repeatedly and non-invasively monitored using PET/CT. The present method is useful for the development of new ATC treatments.
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詳細情報 詳細情報について
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- CRID
- 1910585658881584512
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- NII論文ID
- 500001661291
- 500001428337
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- 本文言語コード
- en
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- データソース種別
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- IRDB
- NDLサーチ