Changes in choroidal thickness in healthy pediatric individuals : a longitudinal study

書誌事項

タイトル
Changes in choroidal thickness in healthy pediatric individuals : a longitudinal study
タイトル別名
  • 健常日本人小児における脈絡膜厚の経時的変化 : 縦断研究
著者
大杉, 英子
著者別名
  • オオスギ, エイコ
  • Ohsugi, Eiko
著者
三田村, 佳典
著者別名
  • ミタムラ, ヨシノリ
  • Mitamura, Yoshinori
著者
四宮, 加容
著者別名
  • シノミヤ, カヨ
  • Shinomiya, Kayo
著者
仁木, 昌徳
著者別名
  • ニキ, マサノリ
  • Niki, Masanori
著者
サノ, ヒロキ
著者別名
  • Sano, Hiroki
著者
長澤, 利彦
著者別名
  • ナガサワ, トシヒコ
  • Nagasawa, Toshihiko
著者
シミズ, ユキコ
著者別名
  • Shimizu, Yukiko
著者
ナガサト, ダイスケ
著者別名
  • Nagasato, Daisuke
著者
タブチ, ヒトシ
著者別名
  • Tabuchi, Hitoshi
学位授与大学
徳島大学
取得学位
博士(医学)
学位授与番号
甲医第1393号
学位授与年月日
2018-11-22

説明

AIM: To investigate the changes in the choroidal thickness in healthy pediatric children in a longitudinal study, and to determine the ocular and systemic parameters that were significantly correlated with the changes in the choroidal thickness. METHODS: This study included 64 eyes of 34 healthy Japanese children with a mean age (±SD) of 4.4 (±0.4)y (range, 3.6-5.8y) at baseline. Swept-source optical coherence tomography (SS-OCT) was used to record images of the retina and choroid at the baseline and after a mean follow-up period of about 1.5y. The 3D raster scan protocol was used to construct the choroidal thickness map. Mean choroidal thickness was calculated for each of the nine sectors of the Early Treatment Diabetic Retinopathy Study grid. Best-corrected visual acuity, axial length, body height, and weight were also measured. Changes in measurements were defined as the baseline values subtracted from the values at the final visit. A generalized estimating equation was used to eliminate the effect of within-subject intereye correlations. RESULTS: The mean central choroidal thickness was significantly reduced during the follow-up period (baseline, 301.8±8.6 μm; final visit, 286.6±8.0 μm, P<0.001). The decrease in the choroidal thickness was greatest in the central sector, followed by the sectors of the inner and outer rings. The inner and outer rings had diameters of 1 to 3 mm and 3 to 6 mm, respectively. The changes in the choroidal thickness in the central, inner ring, and outer ring sectors were significantly and negatively correlated with the age, baseline body height, baseline body weight, and elongation of the axial length. CONCLUSION: These results indicate that the choroidal thickness among preschool-aged Japanese children decreased significantly during the follow-up period. The choroidal thinning is significantly associated with the elongation of axial length. These characteristics should be considered in the evaluation of choroidal thickness in younger children with retinochoroidal disorders.

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