Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus

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Bibliographic Information

Title
Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus
Other Title
  • クラリスロマイシンはインフルエンザAウイルスに感染したマウスにおいて、monocyte chemoattractant protein-1とmatrix metalloproteinase-9の発現誘導を抑制し、肺と心臓における病理学的変化を改善する
Author
Takahashi, Etsuhisa
Alias Name
  • 高橋, 悦久
  • タカハシ, エツヒサ
Author
Indalao, Irene L.
Author
Sawabuchi, Takako
Alias Name
  • サワブチ, タカコ
  • サワブチ, タカコ
Author
Mizuno, Keiko
Alias Name
  • ミズノ, ケイコ
  • ミズノ, ケイコ
Author
Sakai, Satoko
Alias Name
  • サカイ, サトコ
  • サカイ, サトコ
Author
Kimoto, Takashi
Alias Name
  • 木本, 貴士
  • キモト, タカシ
Author
Kim, Hyejin
Author
Kido, Hiroshi
Alias Name
  • 木戸, 博
  • キド, ヒロシ
University
徳島大学
Types of degree
博士（医学）
Grant ID
甲医第1356号
Degree year
2018-01-25

Description

The influenza A virus (IAV)–cytokine–trypsin/matrix metalloproteinase-9 (MMP-9) cycle is one of the important mechanisms of multiple organ failure in severe influenza. Clarithromycin, a macrolide antibiotic, has immune modulatory and anti-inflammatory effects. We analyzed the effects of clarithromycin on the induction of chemokines, cytokines, MMP-9, trypsin, vascular hyper-permeability and inflammatory aggravation in mice with IAV infection. IAV/Puerto Rico/8/34(H1N1) infection increased the levels of monocyte chemoattractant protein- 1 (MCP-1) and cytokines in serum, and MMP-9 and trypsin in serum and/or the lungs and heart. Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-γ. Histopathological examination showed that clarithromycin tended to reduce inflammatory cell accumulation in the lungs and heart. These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9.

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