Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice

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Bibliographic Information

Title
Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice
Other Title
  • マウス歯根膜における咬合過重負荷時のHSP47 の機能的役割
Author
三村, 泰亮
Author
Mimura, Hiroaki
Author
Takaya, Tatsuo
Author
Matsuda, Saeka
Author
Nakano, Keisuke
Author
Muraoka, Rina
Author
Tomida, Mihoko
Author
Okafuji, Norimasa
Author
Fujii, Takeo
Author
Kawakami, Toshiyuki
University
松本歯科大学
Types of degree
博士（歯学）
Grant ID
甲第203号
Degree year
2017-02-09

Description

We carried out an experiment to induce traumatic occlusion in mice periodontal tissue and analyzed the expression of HSP47. Continuous traumatic occlusion resulted to damage and remodeling of periodontal ligament as well as increase in osteoclasts and bone resorption. Four days after traumatic occlusion, osteoclasts did not increase but Howship’s lacunae became enlarged. That is, the persistent occlusal overload can destroy collagen fibers in the periodontal ligament. This was evident by the increased in HSP47 expression with the occlusal overload. HSP47 is maintained in fibroblasts for repair of damaged collagen fibers. On the other hand, osteoclasts continue to increase although the load was released. The osteoclasts that appeared on the alveolar bone surface were likely due to sustained activity. The increase in osteoclasts was estimated to occur after load application at day 4. HSP47 continued to increase until day 6 in experiment 2 but then reduced at day 10. Therefore, HSP47 appears after a period of certain activities to repair damaged collagen fibers, and the activity was returned to a state of equilibrium at day 30 with significantly diminished expression. Thus, the results suggest that HSP47 is actively involved in homeostasis of periodontal tissue subjected to occlusal overload.

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