Discrepancy between systolic and diastolic dysfunction of the left ventricle in patients with Duchenne muscular dystrophy

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Bibliographic Information

Title
Discrepancy between systolic and diastolic dysfunction of the left ventricle in patients with Duchenne muscular dystrophy
Author
Takenaka, Akira
Author
Yokota, Mitsuhiro
Author
Iwase, Masatsugu
Author
Miyaguchi, Kazuhiko
Author
Hayashi, Hiroshi
Author
Saito, Hidehiko
Author
竹中, 晃
Author
横田, 充弘
Author
岩瀬, 正嗣
Author
宮口, 和彦
Author
林, 博史
Author
斎藤, 英彦
University
NAGOYA University
Types of degree
博士(医学)
Grant ID
乙第4351号
Degree year
1993-05-01

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Description

To assess the systolic and diastolic dysfunction of the left ventricle (LV) in relation to age and the severity of impairment in Duchenne muscular dystrophy (DMD), we performed M-mode, two-dimensional and pulsed-wave Doppler echocardi-ography in 45 male subjects with DMD aged 8 to 25 years and in 40 age-matched healthy controls. Systolic dysfunction started in the first decade of life, with some patients showing severe systolic dysfunction in their early teens. This dysfunction, however, did not always depend on the severity of the skeletal muscle disease. No patients with DMD showed an increase in peak atrial velocity and time-velocity integrals of the atrial contraction velocity curve, findings frequently reported to precede the abnormalities in many cardiac diseases; it was thought therefore that these patients had no increase in left atrial compensation. Diastolic dysfunction may not routinely precede or accompany the systolic dysfunction in DMD, in contrast with what is reported in patients with ischaemic or hypertensive heart disease. DMD patients usually show a predominant systolic dysfunction.

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