Bone augmentation of canine frontal sinuses by using a porous α-tricalcium phosphate for implant treatment

Objective: Compared to hydroxyapatite, α-tricalcium phosphate (α-TCP) is more biodegradable and shows better integration during physiological bone remodeling. The objective of this study was to evaluate the effects of porous α-TCP as a tissue-engineered scaffold for maxillary sinus augmentation in a canine model.Materials and methods: Porous α-TCP was prepared by pulverizing an α-TCP block with 80% continuous pore structure. Bilateral sinus floor augmentation surgeries were performed on beagle dogs that were randomly divided into two groups based on the type of repair: the experimental group received a porous α-TCP and titanium (Ti) implant, and the control group received a Ti implant. Peri-implant bone volume (BV) and bone mineral content (BMC) were measured and analyzed using micro-computed tomography (CT) and Villanueva-Goldner staining for histological examination. The intergroup differences were evaluated using Student’s t-tests. Results: Micro-CT images at 12 weeks after surgery showed higher BV and BMC in the experimental group than in the control group (p < 0.05). Histological examination showed high levels of α-TCP even at 4 weeks, but the scaffolds were completely absorbed and new bones integrated to the Ti implants at 12 and 24 weeks. However, no bone formation was observed in the control group throughout the study.Conclusion: Porous α-TCP increased BV and promoted bone mineralization and earlier bone formation in the augmented maxillary sinus. Therefore, this tissue-engineered scaffold might be a better alternative to autologous bone for maxillary sinus augmentation.Keywords: bone augmentation, porous α-tricalcium phosphate, canine frontal sinuses

2016年度

収集根拠 : 博士論文（自動収集）
資料形態 : テキストデータ
コレクション : 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Objective: Compared to hydroxyapatite, α-tricalcium phosphate (α-TCP) is more biodegradable and shows better integration during physiological bone remodeling. The objective of this study was to evaluate the effects of porous α-TCP as a tissue-engineered scaffold for maxillary sinus augmentation in a canine model.Materials and methods: Porous α-TCP was prepared by pulverizing an α-TCP block with 80% continuous pore structure. Bilateral sinus floor augmentation surgeries were performed on beagle dogs that were randomly divided into two groups based on the type of repair: the experimental group received a porous α-TCP and titanium (Ti) implant, and the control group received a Ti implant. Peri-implant bone volume (BV) and bone mineral content (BMC) were measured and analyzed using micro-computed tomography (CT) and Villanueva-Goldner staining for histological examination. The intergroup differences were evaluated using Student’s t-tests. Results: Micro-CT images at 12 weeks after surgery showed higher BV and BMC in the experimental group than in the control group (p < 0.05). Histological examination showed high levels of α-TCP even at 4 weeks, but the scaffolds were completely absorbed and new bones integrated to the Ti implants at 12 and 24 weeks. However, no bone formation was observed in the control group throughout the study.Conclusion: Porous α-TCP increased BV and promoted bone mineralization and earlier bone formation in the augmented maxillary sinus. Therefore, this tissue-engineered scaffold might be a better alternative to autologous bone for maxillary sinus augmentation.Keywords: bone augmentation, porous α-tricalcium phosphate, canine frontal sinuses
2016年度